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Fabrication and Applications of PDMS-Based Microfluidic Devices – A Review

Subhadeep Mukhopadhyay

Abstract


Fabrication techniques of microfluidic devices are a challenging area for researchers since the last few years. Appropriate sealing between the microchannel lid and microchannel structure substrate is necessary to have a leakage-free microfluidic flow in any fabricated microfluidic devices. Many polymers have already been used to fabricate the microfluidic devices. Polydimethylsiloxane (PDMS) is one particular suitable polymer in this purpose. In this educational short review, different fabrication techniques are briefly mentioned that are more suitable to fabricate the PDMS microfluidic devices. This review work is useful as study material for the proposed elective-course on microfluidics (M.Tech, Theory) in the Department of Mechanical Engineering of the National Institute of Technology Arunachal Pradesh, India.

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References


J. C. McDonald, D. C. Duffy, J. R. Anderson, D. T. Chiu, H. Wu, O. J. A. Schueller, G. M. Whitesides. Fabrication of microfluidic systems in poly(dimethylsiloxane), Electrophoresis. 2000; 21: 27–40.

S. Mukhopadhyay, J. P. Banerjee, A. Mathur, M. Tweedie, J. A. McLaughlin, S. S. Roy. Experimental studies of surface-driven capillary flow in PMMA microfluidic devices prepared by direct bonding technique and passive separation of microparticles in microfluidic laboratory-on-a-chip systems, Surf Rev Lett. 2015; 22: 1550050p.

S. Mukhopadhyay, J. P. Banerjee, S. S. Roy, S. K. Metya, M. Tweedie, J. A. McLaughlin. Effects of surface properties on fluid engineering generated by the surface-driven capillary flow of water in microfluidic lab-on-a-chip systems for bioengineering applications, Surf Rev Lett. 2017; 24: 1750041p.

S. Mukhopadhyay. Optimisation of the experimental methods for the fabrication of polymer microstructures and polymer microfluidic devices for bioengineering applications, J Polym Compos. 2016; 4: 8–26p.

S. Mukhopadhyay. Experimental investigations on the interactions between liquids and structures to passively control the surface-driven capillary flow in microfluidic lab-on-a-chip systems to separate the microparticles for bioengineering applications, Surf Rev Lett. 2017; 24: 1750075p.

S. Mukhopadhyay. Experimental investigations on the surface-driven capillary flow of aqueous microparticle suspensions in the microfluidic laboratory-on-a-chip systems, Surf Rev Lett. 2017; 24: 1750107p.

S. Mukhopadhyay. Experimental investigations on the effects of surface modifications to control the surface-driven capillary flow of aqueous working liquids in the PMMA microfluidic devices, Adv Sci Eng Med. 2017; 9: 959–70p.

S. Mukhopadhyay. Report on the separation efficiency with separation time in the microfluidic lab-on-a-chip systems fabricated by polymers in this 21st century of 3rd millennium, J Exp Appl Mech. 2016; 7: 20–37p.

C. W. Tsao, D. L. DeVoe. Bonding of thermoplastic polymer microfluidics, Microfluid Nanofluid. 2009; 6: 1–16p.

H. Becker, L. E. Locascio. Polymer microfluidic devices, Talanta. 2002; 56: 267–87p.




DOI: https://doi.org/10.37628/ijssm.v4i1.52

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