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Growth, Structural, Spectral and Thermal Studies of Etoricoxib Hemi-hydrate Crystals

Sundaram Ramukutty, Esakki Ramachandran

Abstract


Etoricoxib hemi-hydrate, an anti-inflammatory drug of orthorhombic space group Pccn, Z = 8 and lattice parameters a = 20.9876(13) Å, b = 12.6536(8) Å, c = 12.8243(8) Å and of size: 9 × 1.5 × 1.5 mm3 crystals was crystallized by reduction of solubility method in silica gel for the first time in literature. Single crystal X-ray diffraction method was used to characterize the grown crystals. Crystal morphology is correlated with the molecular packing and the growth is found to be prominent along c-axis. Fingerprint absorption bands and functional groups present in title compound were analyzed using Fourier transform infrared spectroscopy (FTIR). Thermo gravimetric analysis (TGA) was carried out to determine thermal decomposition phase of etoricoxib hemi-hydrate.

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DOI: https://doi.org/10.37628/ijssm.v1i1.4

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